InVivo and ExVivo confocal microscopy
VivaScope GmbH
VivaScope GmbH is a German manufacturer of advanced medical technology specializing in confocal laser scanning microscopy (CLSM). Based in Munich, the company offers innovative solutions for in vivo and ex vivo diagnostics through instant digital imaging. VivaScope is part of the MAVIG tradition and is an international leader in the field of non-invasive "optical biopsy", being present in hospitals, clinics and research centers worldwide. Its products support fast and accurate decisions in dermatology, oncology, digital pathology and other medical specialties.
VivaScope - leader in digital imaging for non-invasive optical biopsies.
VivaScope InVivo
The VivaScope In Vivo (models 1500 and 3000) offers an innovative optical imaging solution that allows skin to be examined directly on the patient without the need for biopsy. The systems use confocal laser scanning confocal microscopy (CLSM) to provide real-time images of skin layers with subcellular resolution.
→ Allows assessment of suspicious lesions, treatment monitoring and rapid decisions, especially in dermatologic oncology.
The devices are compact, mobile and easy to integrate into daily practice. The VivaScope 1500 is designed for use on the examination table, while the portable 3000 model allows flexible investigations in the outpatient setting or in hard-to-reach areas.
→ Intuitive interface, dedicated software, connectivity with clinical systems and real-time image capture - all designed for efficiency and ease of use.
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Advanced technology and performance
The system uses a laser beam that scans layer by layer, providing high-resolution images of the epidermis and dermis. Details such as cellular architecture, tumor boundaries and melanocyte characteristics become easily visible without any invasive processing.
→ Images can be processed in real time, flagged and archived, providing fast and efficient clinical diagnostic support.
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Fields of application
Ideal in dermatology, VivaScope InVivo is used to screen for pigmented lesions, basal cell carcinoma, melanoma or other skin conditions. It is also valuable in clinical trials and research.
→ Also applicable in aesthetic medicine or post-therapy monitoring, suitable for hospitals, private clinics or university centers.
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Advantages and benefits
VivaScope InVivo Provides a clear, pain-free, incision-free and risk-free image for the patient. Enables rapid diagnosis and increases patient comfort in the evaluation process.
→ Reduces indirect costs and the number of unnecessary biopsies, contributing to a more efficient and safer clinical experience.
VivaScope ExVivo
Vivascope Ex Vivo is an advanced instant digital pathology solution designed for the rapid and direct evaluation of freshly excised tissues during surgery or immediately after procurement. The system allows for the acquisition of digital images with an appearance similar to classic H&E (hematoxylin and eosin) staining, without requiring traditional histological processing steps. Analysis can be performed in minutes, providing essential real-time information to support clinical decisions.
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Advanced technology and performance
Vivascope Ex Vivo utilizes confocal laser scanning microscopy (CLSM) technology, which combines two laser sources with different wavelengths for simultaneous capture of reflectance and fluorescence images. The data obtained are processed by advanced software algorithms, resulting in pseudo-colored images that faithfully reproduce the H&E histological appearance, with subcellular resolution.
The technology allows for tissue morphology examination without fixation, sectioning, or conventional staining. The system is DICOM-compatible and can be integrated into the hospital's digital infrastructure, and its mobile design makes it easy to use directly in the operating room or other clinical areas.
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Fields of application
Vivascope Ex Vivo is intended for a wide range of clinical applications where rapid tissue evaluation is critical:
→ evaluation of tumor margins in oncological surgery to support intraoperative decisions;
→ immediate examination of biopsies, including small tissue samples and fine needle aspirates (FNA/FNB);
→ analysis of dermatological, breast, gastrointestinal, and other types of tissue samples requiring rapid diagnosis.
Through these applications, the system contributes to optimizing the surgical workflow and improving patient management.
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Advantages and benefits
The use of Vivascope Ex Vivo technology offers multiple benefits compared to traditional histological analysis methods:
obtaining images and evaluating the specimen within approximately 3–5 minutes of collection;
→ reducing operator times and supporting real-time clinical decisions;
maintaining the integrity of the specimen, which can subsequently be used for histological, immunohistochemical, or molecular analyses;
→reduction or elimination of the need for frozen sections and laborious laboratory processes;
→ the possibility of remote consultation and telepathology, facilitating collaboration with external specialists;
→ Operational flexibility due to the mobile design, which allows the equipment to be used in multiple clinical spaces.
Through the combination of speed, accuracy, and versatility, Vivascope Ex Vivo represents a modern and efficient solution for digital pathology and intraoperative diagnostics.
RESOURCE
Catalog
Check out our briefing materials to explore how technologies Vivascope InVivo and ExVivo is revolutionizing dermatological diagnostics. The brochures available include detailed information on how it works, the advantages of non-invasive examination and direct clinical applications in the evaluation of skin lesions.
Download the brochures and discover how InVivo & ExVivo imaging can support fast and accurate medical decisions.
Media
Watch below videos and demonstrations illustrating how VivaScope InVivo & ExVivo support rapid, non-invasive diagnosis directly on the patient's skin.
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